Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells
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- 作者：Andrew D. King1 ; 2 ; Kevin Huang1 ; 3 ; Liudmilla Rubbi4 ; Shuo Liu5 ; Cun-Yu Wang3 ; Yinsheng Wang5 ; Matteo Pellegrini4 ; Guoping Fan1 ; 6 ; gfan@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA methylation ; histone modifications ; chromatin ; polycomb ; embryonic stem cells ; enhancers ; promoters ; gene regulation ; epigenetics
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：289-302
- 全文大小：4532 K
文摘
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DNA methylation reversibly regulates H3K27me3 and H3K27ac at both promoters and enhancers
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H3K27me3 regulation by DNA methylation differs between bivalent and silent promoters
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Regulation of H3K27me3 is dependent on 5mC and requires DNMT catalytic activity