First total synthesis of two new heterocyclic compounds: Bretschneiderazines A and B

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• 作者：Qing Chao Liu^a ; ^{Liuqc21@nwu.edu.cn"" rel=""nofollow} ; Tian Tian Guo^b ; Zheng Fan^a ; Dong Li^a ; Wen Hong Li^a
• 关键词：Heterocyclic compounds ; Bretschneiderazines ; Directed lithiation ; Synthesis
• 刊名：Chinese Chemical Letters
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：22
• 期：7
• 页码：801-803
• 全文大小：131 K

文摘

Facile synthesis of the two new natural heterocyclic compounds bretschneiderazines A (2) and B (3), isolated from an extract of the stems of Bretschneidera sinensis, is reported. We employed the cyclization reaction of benzamide by directed lithiation and sequential treatment with sulfur and phosgene as key steps. All new compounds have been fully characterized by means of IR, ¹H NMR, ¹³C NMR, and HRMS.