Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease

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• 作者：Gianluigi Lunardi ; Salvatore Galati ; Domenicantonio Tropepi ; Vincenzo Moschella ; Livia Brusa ; Mariangela Pierantozzi ; Aless ; ro Stefani ; Silvia Rossi ; Francesco Fornai ; Ernesto Fedele ; Paolo Stanzione
• 关键词：Parkinson's disease progression ; Cerebrospinal fluid ; Dopamine turnover ; Dyskinesia
• 刊名：Parkinsonism and Related Disorders
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：15
• 期：5
• 页码：383-389
• 全文大小：529 K

文摘

To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS).

DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN group.

Our data show that disease progression produces an early large decay of DA levels, followed by a stabilization. On the contrary, a late change in DA turnover (increased HVA/DA ratio) is documented in patients with longer disease duration. Our results suggest that the appearance of dyskinesia may not be related to a further loss of DA terminals but to a different, abnormal, DA turnover.