Integrase inhibitors in late pregnancy and rapid HIV viral load reduction

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• 作者：Lisa Rahangdale ; MD ; MPH^a ; ^{lisa_rahangdale@med.unc.edu" class="auth_mail" title="E-mail the corresponding author} ; Jordan Cates ; MSPH^g ; JoNell Potter ; PhD^b ; Martina L. Badell ; MD^h ; Dominika Seidman ; MD^k ; Emilly S. Miller ; MD ; MPH^c ; Jenell S. Coleman ; MD ; MPH^j ; Gweneth B. Lazenby ; MD ; MSCR^d ; Judy Levison ; MD^e ; William R. Short ; MD ; MPH^l ; Sigal Yawetz ; MD^m ; Andrea Ciaranello ; MD ; MPHⁿ ; Elizabeth Livingston ; MD^f ; Lunthita Duthely ; EdD ; MS^b ; Bassam H. Rimawi ; MDⁱ ; Jean R. Anderson ; MD^j ; Elizabeth M. Stringer ; MD^a ; HOPES (HIV OB Pregnancy Education Study) Group
• 关键词：HIV ; integrase inhibitors ; pregnancy
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：214
• 期：3
• 页码：385.e1-385.e7
• 全文大小：378 K

文摘

Minimizing time to HIV viral suppression is critical in pregnancy. Integrase strand transfer inhibitors (INSTIs), like raltegravir, are known to rapidly suppress plasma HIV RNA in nonpregnant adults. There are limited data in pregnant women.

Objective

We describe time to clinically relevant reduction in HIV RNA in pregnant women using INSTI-containing and non-INSTI-containing antiretroviral therapy (ART) options.

Study Design

We conducted a retrospective cohort study of pregnant HIV-infected women in the United States from 2009 through 2015. We included women who initiated ART, intensified their regimen, or switched to a new regimen due to detectable viremia (HIV RNA >40 copies/mL) at ≥20 weeks gestation. Among women with a baseline HIV RNA permitting 1-log reduction, we estimated time to 1-log RNA reduction using the Kaplan-Meier estimator comparing women starting/adding an INSTI in their regimen vs other ART. To compare groups with similar follow-up time, we also conducted a subgroup analysis limited to women with ≤14 days between baseline and follow-up RNA data.

Results

This study describes 101 HIV-infected pregnant women from 11 US clinics. In all, 75% (76/101) of women were not taking ART at baseline; 24 were taking non-INSTI containing ART, and 1 received zidovudine monotherapy. In all, 39% (39/101) of women started an INSTI-containing regimen or added an INSTI to their ART regimen. Among 90 women with a baseline HIV RNA permitting 1-log reduction, the median time to 1-log RNA reduction was 8 days (interquartile range [IQR], 7-14) in the INSTI group vs 35 days (IQR, 20-53) in the non-INSTI ART group (P < .01). In a subgroup of 39 women with first and last RNA measurements ≤14 days apart, median time to 1-log reduction was 7 days (IQR, 6-10) in the INSTI group vs 11 days (IQR, 10-14) in the non-INSTI group (P < .01).

Conclusion

ART that includes INSTIs appears to induce more rapid viral suppression than other ART regimens in pregnancy. Inclusion of an INSTI may play a role in optimal reduction of HIV RNA for HIV-infected pregnant women presenting late to care or failing initial therapy. Larger studies are urgently needed to assess the safety and effectiveness of this approach.