Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice

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• 作者：Yong Chen ; Jian-wei Chen ; Sha-sha Xu ; Yu Wang ; Xiang Li ; ^{lixiang_8182@163.com} ; Bao-chang Cai ; Nai-bing Fan
• 关键词：Annonaceous acetogenins ; In vivo ; HepS ; S180 ; Xenograft
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：15 April, 2012
• 年：2012
• 卷：22
• 期：8
• 页码：2717-2719
• 全文大小：205 K

文摘

Annonaceous acetogenins (ACGs), as one of the most powerful groups of mitochondrial complex I inhibitors, exhibit potent cytotoxic activity against a variety of human tumor cell lines. In this study, the antitumor activities of three main types of ACGs were investigated using S180 and HepS xenografts bearing mice simultaneously. The results revealed that select ACGs suppressed tumor growth in a dose-dependent fashion. Tested ACGs showed more selective antitumor activity against HepS. Furthermore, adjacent bis-THF ACGs were more active than mono-THF and nonadjacent bis-THF ACGs against HepS and S180; nonadjacent bis-THF ACGs were more active than mono-THF ACGs against S180, but mono-THF ACGs were more potent than nonadjacent bis-THF ACGs against HepS.