Advances in understanding the mechanisms of mercury toxicity in wild golden grey mullet (Liza aurata) by ¹H NMR-based metabolomics

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• 作者：Tiziana Cappello^a ; ^{tcappello@unime.it} ; Patrí ; cia Pereira^b ; Maria Maisano^a ; Angela Mauceri^a ; Má ; rio Pacheco^b ; Salvatore Fasulo^a
• 关键词：Mercury ; Fish ; Gills ; NMR-based metabolomics ; Environmental health assessment
• 刊名：Environmental Pollution
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：219
• 期：Complete
• 页码：139-148
• 全文大小：967 K
• 卷排序：219

文摘

Mechanisms of mercury toxicity were investigated in gills of wild fish (Liza aurata). 1H NMR-based metabolomics and multivariate statistical analysis were applied. Hg interfered with ion-osmoregulation, as well with energy and protein metabolism. Vulnerability in gill respiratory activity and antioxidant defence system was observed. The environmental metabolomics is an effective tool in ecotoxicological studies.