Enantioselective total synthesis of natural 11,12-epoxycembrene-C
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- 作者：Li ; Yulin ; Liu ; Zuosheng ; Lan ; Jiong ; Li ; Jing ; Peng ; Lizeng ; Li ; Weidong Z. ; Li ; Ying ; Chan ; Albert S. C.
- 关键词：cembrane diterpenoid ; McMurry coupling ; Sharpless epoxidation ; 11 ; 12-epoxycembrene-C ; total synthesis
- 刊名：Tetrahedron Letters
- 出版年：2000
- 出版时间：September 23, 2000
- 年：2000
- 卷：41
- 期：3
- 页码：7465-7469
- 全文大小：120 K
文摘
The first enantioselective total synthesis of (+)-11,12-epoxycembrene-C (1), a novel naturally occurring cembranoxide isolated from tropical marine soft coral, was achieved via a general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as key steps from readily available starting materials.