High-frequency electrical stimulation of the subthalamic nucleus excites target structures in a model using c-fos immunohistochemistry
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- 作者：S. Shehaba ; s.shehab@uaeu.ac.ae" class="auth_mail ; C. D&rsquo ; souzaa ; M. Ljubisavljevicb ; P. Redgravec
- 关键词：EPN ; entopeduncular nucleus ; GP ; globus pallidus ; HFS ; high-frequency stimulation ; PD ; Parkinson&rsquo ; s disease ; SNr ; substantia nigra pars reticulate ; STN ; subthalamic nuclei
- 刊名：Neuroscience
- 出版年：13 June 2014
- 年：2014
- 卷：270
- 期：Complete
- 页码：212-225
- 全文大小：4699 K
文摘
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Exposure to ether induced c-fos in the STN, GP, EPN and SNr.
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STN inhibition with muscimol suppressed ether-evoked c-fos expression in the GP, EPN and SNr.
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STN-HFS increased c-fos expression in GP, EPN and SNr above that induced by ether alone.
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Kainic acid injection and HFS in the STN induced c-fos expression in the GP, EPN and SNr.
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STN-HFS excites rather than inhibits efferent target structures.