Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation
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- 作者：Moniek Riemersma1 ; 2 ; 3 ; D. Sean Froese4 ; Walinka van Tol1 ; 2 ; Udo F. Engelke2 ; Jolanta Kopec4 ; Monique van Scherpenzeel1 ; 2 ; Angel Ashikov1 ; 2 ; Tobias Krojer4 ; Frank von Delft4 ; Marco Tessari5 ; Anna Buczkowska6 ; Ewa Swiezewska6 ; Lucas T. Jae7 ; Thijn R. Brummelkamp7 ; Hiroshi Manya8 ; Tamao Endo8 ; Hans van Bokhoven3 ; 9 ; Wyatt W. Yue4 ; wyatt.yue@sgc.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Dirk J. Lefeber1 ; 2 ; dirk.lefeber@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Chemistry & Biology
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：22
- 期：12
- 页码：1643-1652
- 全文大小：2301 K
文摘
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ISPD knockout cells show normal POMT activity and isoprenoid production
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ISPD appends a novel domain to its conserved N-terminal cytidyltransferase core
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Human ISPD shows cytidyltransferase activity toward pentose phosphate sugars
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Human ISPD is involved in the synthesis of a novel nucleotide sugar in human