PLB2_Tau mice express mutant human Tau without gross overexpression.

Age-dependent Tau phosphorylation coincides with onset of behavioural deficits.

Behavioural and emotional abnormalities are prominent, early occurring phenotypes.

Robust semantic-like but subtle spatial memory impairments are evident.

Reduced stage- and region-specific EEG changes and mild changes in hippocampal synaptic transmission were identified.