Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches
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- 作者：Coralie Dumont ; Joã ; o Barroso ; Izabela Matys ; Andrew Worth ; Silvia Casati ; silvia.casati@ec.europa.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACE ; acetone ; AOO ; acetone ; olive oil (4 ; 1 by volume) ; DMF ; dimethylformamide ; EC3 ; effective concentration inducing a stimulation index of 3 ; ETOH/DEP ; Ethanol/diethylphthalate ; EXT ; extreme (ECETOC classification) ; IDR ; Insufficient Dose Response ; MOD ; moderate (ECETOC classification) ; NEG ; negative ; SI ; stimulation index ; TG ; Test Guideline ; TMPTA ; ethyl-2-(hydroxymethyl)-1 ; 3-propanediol triacrylate
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：220-228
- 全文大小：985 K
文摘
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Descriptive analyses of LLNA results show variability in the classification outcomes
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When considering potency classification, the strongest potency classes seem to be the most reliable
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It was equally likely that discordant studies for a chemical led to a more vs a less severe potency classification