Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 1. Underlying physical organic chemistry principles and the extent to which they are represented in the LLNA validation dataset
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- 作者：D.W. Robertsa ; D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author ; A.M. Apib ; G. Patlewiczc ; 1 ; T.W. Schultzd
- 关键词：Skin sensitization ; Reactivity ; Electrophilicity ; Hydrophobicity ; Relative Alkylation Index (RAI) ; Skin penetration
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：247-254
- 全文大小：1061 K
文摘
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Chemical mechanisms of skin sensitization are reviewed.
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In vivo test methods including the LLNA are discussed.
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Ranges of key physico-chemical parameters are extracted to characterise one type of applicability domain for the LLNA.