Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro

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• 作者：Alessandra Giorgetti^a ; ^b ; ^{agiorgetti@carrerasresearch.org} ; Julio Casta&ntilde ; o^a ; Clara Bueno^a ; Rafael Dí ; az de la Guardia^a ; Mario Delgado^c ; Anna Bigas^d ; Lluis Espinosa^d ; Pablo Menendez^a ; ^e ; ^{pmenendez@carrerasresearch.org}
• 刊名：Experimental Hematology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：45
• 期：Complete
• 页码：85-93.e2
• 全文大小：2061 K
• 卷排序：45

文摘

Proinflammatory signaling does not improve definitive hematopoietic stem cell specification in vitro. Primitive human pluripotent stem cell hematopoietic derivatives lack an innate proinflammatory phenotype. Proinflammatory cytokines do not drive blood formation from human pluripotent stem cells using current protocols.