The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose

详细信息    查看全文

• 作者：Mehmet Baykal^a ; Necati Gö ; kmen^a ; Alper Doğan^a ; Serhat Erbayraktar^b ; Osman Yılmaz^c ; Elvan Ocmen^a ; Hale Aksu Erdost^a ; ^{hale.erdost@deu.edu.tr} ; Atalay Arkan^a
• 关键词：Rocuronium ; Seizure ; Central nervous system ; Rat
• 刊名：Brazilian Journal of Anesthesiology (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：67
• 期：1
• 页码：1-5
• 全文大小：342 K
• 卷排序：67

文摘

The aim of this study was to investigate the effects of intracerebroventricularly administered rocuronium bromide on the central nervous system, determine the seizure threshold dose of rocuronium bromide in rats, and investigate the effects of rocuronium on the central nervous system at 1/5, 1/10, and 1/100 dilutions of the determined seizure threshold dose.MethodsA permanent cannula was placed in the lateral cerebral ventricle of the animals. The study was designed in two phases. In the first phase, the seizure threshold dose of rocuronium bromide was determined. In the second phase, Group R 1/5 (n = 6), Group 1/10 (n = 6), and Group 1/100 (n = 6) were formed using doses of 1/5, 1/10, and 1/100, respectively, of the obtained rocuronium bromide seizure threshold dose.ResultsThe rocuronium bromide seizure threshold value was found to be 0.056 ± 0.009 μmoL. The seizure threshold, as a function of the body weight of rats, was calculated as 0.286 μmoL/kg−1. A dose of 1/5 of the seizure threshold dose primarily caused splayed limbs, posturing, and tremors of the entire body, whereas the dose of 1/10 of the seizure threshold dose caused agitation and shivering. A dose of 1/100 of the seizure threshold dose was associated with decreased locomotor activity.ConclusionsThis study showed that rocuronium bromide has dose-related deleterious effects on the central nervous system and can produce dose-dependent excitatory effects and seizures.