Phage-display screening identifies LMP1-binding peptides targeting the C-terminus region of the EBV oncoprotein
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- 作者：Nihel Ammous-Boukhrisa ; Amor Mosbahb ; Emna Sahlia ; Wajdi Ayadia ; Boutheina Hadhri-Guigaa ; Ameur Ché ; rifb ; Ali Gargouria ; Raja Mokdad-Gargouria ; raja.gargouri@cbs.rnrt.tn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LMP1 ; Phage display ; Oncoprotein ; Peptide ; Molecular docking
- 刊名：Peptides
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：73-79
- 全文大小：1349 K
文摘
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C-terminus LMP1 region was produced in E. coli as recombinant protein.
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A phage display library was screened with the recombinant protein as target.
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Two peptides (FO5,and NO4) recognize specifically the CTAR of LMP1.
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NO4, FO5 are potential candidates able to modulate the activity of LMP1.