Tumor Response After Stereotactic Body Radiation Therapy to Nonspine Bone Metastases: An Evaluation of Response Criteria

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• 作者：Rachel McDonald ; BSc(C)^&lowast ; ; Linda Probyn ; MD^&dagger ; ; Ian Poon ; MD^&lowast ; ; Darby Erler ; MRTT^&lowast ; ; Drew Brotherston ; MD(C)^&lowast ; ; Hany Soliman ; MD^&lowast ; ; Patrick Cheung ; MD^&lowast ; ; Hans Chung ; MD^&lowast ; ; William Chu ; MD^&lowast ; ; Andrew Loblaw ; MD^&lowast ; ; Nemica Thavarajah ; BScN(C)^&lowast ; ; Catherine Lang ; BSc^&dagger ; ; Lee Chin ; PhD^&Dagger ; ; Edward Chow ; MBBS^&lowast ; ; ^{Edward.Chow@sunnybrook.ca" class="auth_mail" title="E-mail the corresponding author} ; Arjun Sahgal ; MD^&lowast ;
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2015
• 出版时间：15 November 2015
• 年：2015
• 卷：93
• 期：4
• 页码：879-881
• 全文大小：170 K

文摘

To evaluate the applicability of the Response Evaluation Criteria in Solid Tumors (RECIST 1.1) and University of Texas MD Anderson (MDA) Cancer Center criteria in the setting of stereotactic body radiation therapy (SBRT) to nonspine bone metastases.

Methods

Patients who were treated with SBRT to nonspine bone metastases were identified by retrospective chart review. An independent musculoskeletal radiologist evaluated response to treatment using computed tomography (CT) scans.

Results

Thirty-three patients were treated to 42 nonspine bone metastases. The most common primary cancer cites were renal cell carcinoma (RCC) (33.3%), lung (24.2%), and prostate (18.2%). Bone metastases were either mainly lytic (57.1%), mainly sclerotic (28.6%), or mixed (14.3%). When lytic and sclerotic lesions were evaluated according to RECIST 1.1, local control (LC) was 83%, 85%, 88%, and 80% for those with CT imaging between months 1 to 3, 4 to 6, 7 to 9, and 10 to 12, respectively. When evaluated by the MDA criteria by density, LC within each time period was slightly greater. Overall LC decreased considerably when evaluated by MDA in terms of size.

Conclusions

Consensus definitions of response are required as they have implications on clinical trials and disease management. Without consistent response criteria, outcomes from clinical trials cannot be compared and treatment efficacy remains undetermined.