Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 3. Apparent discrepancies between LLNA and GPMT sensitisation potential: False positives or differences in sensitivity?
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- 作者：David W. Robertsa ; D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Terry W. Schultzb ; Anne Marie Apic
- 关键词：Unsaturated fatty acids ; Surfactants ; Autoxidation
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：260-267
- 全文大小：767 K
文摘
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Several fatty acids and surfactants test positive for skin sensitisation in the LLNA.
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They test negative in guinea pigs and have been argued to be LLNA false positives.
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Our SAR analysis reveals that the LLNA positives have alerts for autoxidation by air.
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The LLNA protocol is particularly favourable for autoxidation.
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These chemicals are true LLNA positives but do not cause allergy in man.