Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 2. The biological variability of the murine Local Lymph Node Assay (LLNA) for skin sensitisation
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- 作者：David W. Robertsa ; D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Anne Marie Apib ; Aynur O. Aptulac
- 关键词：LLNA ; Biological variability ; Non-animal prediction ; QMM
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：255-259
- 全文大小：317 K
文摘
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The biological variability of LLNA EC3 values is within a factor of 2.
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This is similar to variability physical measurements such as partition coefficients.
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It is similar to residual SDs in QMMs relating chemical parameters to EC3.
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LLNA biological variability does not cause poor performance of non-animal methods.