Label-free detection of 3-nitro-l-tyrosine (3-NT) in PBS and human serum.
Nickel-doped-graphene (NDG) receptor with high binding specificity to 3-NT.
Phase detecting localized surface plasmon resonance (LSPR) interferometric biosensor.
Detection limit of 3-NT in PBS was found to be 0.13 pg/ml.
The linear dynamic range covers 0.5 pg/ml to 1 ng/ml, i.e. four orders of magnitude.
A direct chemisorption immunoassay for early diagnostic of 3-NT related disorders in rapid, economical, and non-invasive manners.