- 作者：S. Trefler ; A. Rodr铆guez ; I. Mart铆n-Loeches ; V. Sanchez ; J. Mar铆n ; M. Llaurad贸 ; M. Romeu ; E. D铆az ; R. Nogu茅s ; M. Giralt
- 关键词：Oxidative stress ; 2009 Influenza A/H1N1 virus ; Bacterial pneumonia ; Community-acquired pneumonia
- 刊名：Medicina Intensiva
- 出版年：March, 2014
- 年：2014
- 卷：38
- 期：2
- 页码：73-82
- 全文大小：335 K
Objective
A comparison was made of the oxidative stress (OS) levels of patients with either viral or bacterial severe community-acquired pneumonia (sCAP) and of patients without infection (healthy volunteers (HV) and patients with acute myocardial infarction (AMI)).Design
A prospective observational study was made.
Patients
Critically ill patients with sCAP.
Variables
The TBARS level was measured as an index of oxidative injury. SOD, CAT and redox glutathione system (GSH, GSSG, GR, GPx) activities were measured as reflecting antioxidant capacity. Severity of illness was assessed by the APACHE II, SOFA and SIRS scores.
Results
Thirty-seven subjects were included: 15 patients with CAP (12 of bacterial origin [BCAP] and 3 due to 2009 A/H1N1 virus [VCAP]), 10 HV and 12 AMI patients. Intensive care CAP mortality was 26.7% (n = 4). Plasmatic TBARS levels were higher in CAP patients than in HV, but similar to those recorded in AMI patients. In contrast, VCAP was associated with lower TBARS levels, and some components of the glutathione redox system were higher in BCAP patients and HV. The OS levels did not differ between survivors and non-survivors.
Conclusion
Our results suggest the occurrence of higher OS in sCAP patients compared with HV. In contrast, lower TBARS levels were observed in VCAP patients, suggesting an increase of antioxidant activity related to the redox glutathione system. However, further research involving a larger cohort is needed in order to confirm these findings.