The role of mylohyoid flap in the treatment of bisphosphonate-related osteonecrosis of the jaws

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• 作者：Thomas Mü ; cke ; ^{th.mucke@gmx.de" class="auth_mail" title="E-mail the corresponding author} ; ^{thomas.muecke@tum.de" class="auth_mail" title="E-mail the corresponding author} ; Steffen Koerdt ; Maximilian Jung ; David A. Mitchell ; Klaus-Dietrich Wolff ; Marco Rainer Kesting ; Denys John Loeffelbein
• 关键词：Bisphosphonates ; Jaws ; Osteonecrosis ; Treatment outcome ; Recurrence ; Microvascular free flap
• 刊名：Journal of Cranio-Maxillofacial Surgery
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：44
• 期：4
• 页码：369-373
• 全文大小：525 K

文摘

Surgical treatment of bisphosphonate-related osteonecrosis of the jaws (BRONJ) combines excision of adequate damaged bone and watertight coverage by appropriate vascularized tissue. Local tissues are preferred when possible. This study compares local mucoperiosteal flaps with mylohyoid flaps with special emphasis on their influence on wound healing.

Material and methods

A total of 195 patients with BRONJ in the mandible were included in this prospective study. The control group (n = 169) were treated with a mucoperiosteal flap, whereas patients of the study group (n = 26) received a mylohyoid flap.

Results

Recurrence of BRONJ was significantly reduced (p = 0.023) as was extent of necrosis (p = 0.001) in patients with mylohyoid flaps.

Discussion

This study demonstrates the importance of a sufficient mucosal coverage in surgical treatment of BRONJ. The mylohyoid flap provides an additional tissue coverage, which seems to account for the significantly reduced rate of disease recurrence.

Conclusion

The vascularized mylohyoid flap is an important tool in the complex and challenging surgical care of BRONJ.