Regulation of PAI-1 Expression by Genetic Polymorphisms: Impact on Atherogenesis

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• 作者：Nordt ; Thomas K. ; Lohrmann ; Jens ; Bode ; Christoph
• 关键词：plasminogen activator inhibitor ; Polymorphisms ; Arteriosclerosis ; Cardiovascular disease
• 刊名：Thrombosis Research
• 出版年：2001
• 出版时间：September 30, 2001
• 年：2001
• 卷：103
• 期：Supplement 1
• 页码：S1-S5
• 全文大小：58.9 K

文摘

Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell cultur epidemiological, and clinical studies) and their role in the development of cardiovascular disease.