- 作者：Phuong L. Mai ; Michael Friedl ; er ; Kathy Tucker ; Kelly-Anne Phillips ; David Hogg ; Michael A.S. Jewett ; Radka Lohynska ; Gedske Daugaard ; Sté ; phane Richard ; Catherine Bonaï ; ti-Pellié ; Axel H
- 关键词：Testicular neoplasms ; Familial ; Epidemiology ; Clinicopathologic characteristics
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2010
- 出版时间：September-October 2010
- 年：2010
- 卷：28
- 期：5
- 页码：492-499
- 全文大小：198 K
ObjectivesFamilial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.Materials and methods
Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.
Results
A majority (88.5 % ) of families had only 2 cases of TGCT. Men with seminoma (50 % of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (κ = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.
Conclusions
Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.