Chemotherapy and drug resistance status of malaria parasite in northeast India

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• 作者：Diganta Goswami^a ; ^{digantagos@yahoo.co.in} ; Indra Baruah^a ; Sunil Dhiman^a ; Bipul Rabha^a ; Vijay Veer^a ; Lokendra Singh^b ; Dhirendra Kumar Sharma^c
• 关键词：Malaria ; Chemotherapy ; Antimalarials ; Drug resistance
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：6
• 期：7
• 页码：583-588
• 全文大小：660 K

文摘

India reports the highest number of malaria cases in Southeast Asia, of which Plasmodium falciparum contribute more than half of the cases every year. North eastern states of India contribute only 3.96 % of country's population but account for >10 % of total reported malaria cases, 11 % of Plasmodium falciparum cases and 20 % of malaria related deaths annually. In India, chloroquine resistance was reported for the first time from northeast region and since then chloroquine treatment failure is being reported from many parts of the region. Increased chloroquine treatment failure has led to change of the drug policy to artemisinin combination therapy as first line of malaria treatment in the region. However, replacing chloroquine to artemisinin combination therapy has not shown significant difference in the overall malaria incidence in the region. The present review addresses the current malaria situation of northeastern region of India in the light of antimalarials drug resistance.