Adsorptive stripping voltammetric determination of anticancer drug lomustine in biological fluids using in situ mercury film coated graphite pencil electrode
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- 作者：Yassien Temerk ; Temerk44@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Mohamed Ibrahim ; Hossieny Ibrahim ; Mohamed Kotb
- 关键词：Lomustine ; Anticancer drug ; Mercury film electrode ; Adsorptive stripping voltammetry ; Biological fluids
- 刊名：Journal of Electroanalytical Chemistry
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：760
- 期：Complete
- 页码：135-142
- 全文大小：852 K
文摘
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In situ mercury film coated graphite pencil electrode (MF/GPE) was applied for determination of lomustine (LMT).
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Parameters optimization for preparation of MF/GPE was examined.
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The modified electrode showed high sensitivity in wide linear range and low detection limit.
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The electrochemical parameters for the reduction of LMT at the MF/GPE were calculated.
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The modified electrode was successfully applied for determination of LMT in human fluids.