Interactions of the spin-labeled chloroethylnitrosourea SLCNUgly with electrode-supported lipid films

详细信息    查看全文

• 作者：Bilyana Tacheva^a ; Radostina Georgieva^a ; ^b ; Miroslav Karabaliev^a ; ^{miroslav.karabaliev@trakia-uni.bg" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Electrode supported thin lipid films ; drug-membrane interactions ; nitrosourea ; voltammetry
• 刊名：Electrochimica Acta
• 出版年：2016
• 出版时间：20 February 2016
• 年：2016
• 卷：192
• 期：Complete
• 页码：439-447
• 全文大小：1365 K

文摘

The spin-labeled chloroethylnitrosourea containig glycine SLCNUgly is an analogue of the clinically used nitrosourea drug lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, CCNU), showing promising properties and features in vitro as well as in vivo. In this work the interaction of SLCNUgly with a lipid model membrane is investigated. The presented results indicate penetration of the drug in the membranes without causing defects of the lipid structure and reveal the potential of both SLCNUgly and electrode-supported lipid films as models for investigating nitrosourea drugs-membrane interactions.