Acute testicular toxicity induced by melamine alone or a mixture of melamine and cyanuric acid in mice
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- 作者：Lingling Chang ; Ruiping She ; sheruiping@126.com" class="auth_mail ; Longhuan Ma ; Hua You ; Fengjiao Hu ; Tongtong Wang ; Xiao Ding ; Zhaojie Guo ; Majid Hussain Soomro
- 关键词：Melamine ; Cyanuric acid ; Transmission electron microscopy ; Blood&ndash ; testis barrier ; Apoptosis ; Vimentin
- 刊名：Reproductive Toxicology
- 出版年：July 2014
- 年：2014
- 卷：46
- 期：Complete
- 页码：1-11
- 全文大小：5820 K
文摘
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We for the first time demonstrated the acute testicular toxicity of melamine (MA) alone or melamine–cyanuric acid mixture (MC) in mice.
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MA and MC caused testicular and epididymal lesions and increased sperm abnormality.
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MA and MC caused disruption of blood–testis barrier.
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MA and MC induced germ cell apoptosis.
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MA and MC collapsed Sertoli cell vimentin filaments.