What explains the differences between centres in the European screening trial? A simulation study

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• 作者：Jaakko Nevalainen^a ; ^{jaakko.nevalainen@uta.fi} ; Ulf-Hå ; kan Stenman^b ; Teuvo L. Tammela^c ; Monique Roobol^d ; Sigrid Carlsson^e ; ^f ; Kirsi Talala^g ; Fritz H. Schrö ; der^d ; Anssi Auvinen^a
• 关键词：Longitudinal PSA model ; Prostate cancer ; Prostate-specific antigen ; Screening ; Simulation model
• 刊名：Cancer Epidemiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：46
• 期：Complete
• 页码：14-19
• 全文大小：837 K
• 卷排序：46

文摘

Differences in the screening interval and PSA cut-off did not explain differences in screening impact by ERSPC centre. Less intensive screening algorithm may be preferred. The small screening impact in the Finnish centre was largely due to a low prostate cancer mortality in the Finnish control arm. Contamination complicates the assessment of maximal efficiency of prostate cancer screening in ERSPC as a whole.