DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop
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- 作者：Dipta Sengupta ; Moonmoon Deb1 ; Sandip Kumar Rath ; Swayamsiddha Kar ; Sabnam Parbin ; Nibedita Pradhan ; Samir Kumar Patra ; samirp@nitrkl.ac.in" class="auth_mail" title="E-mail the corresponding author ; skpatra_99@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; MiR-152 ; DNMT1 ; CpG-island ; H3K4me3 ; CDH1 gene
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：346
- 期：2
- 页码：176-187
- 全文大小：3022 K
文摘
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miR-152 and CDH1 repression by DNA methylation is associated with breast cancer progression.
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DNA methylation adjacent to transcriptionally active histone marking H3K4me3 silence miR-152 gene.
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Ectopic expression of miR-152 modulates protein expression of DNMT1 down and CDH1 up.
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Ectopic expression of DNMT1 leads to repression of miR-152 and CDH1 genes.
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CDH1 expression by miR-152/DNMT1 switch inhibits cell migration.