NFkB/AP-1-mediated DNA looping is involved in TNF-伪-induced MMP-9 up-regulation.
TNF-伪 reduces HDAC-1 but increases p300 recruitment to MMP-9 promoter regions.
Histone acetylation increases the level of NFkB/AP-1-mediated DNA looping.
Histone deacetylation reduces the level of NFkB/AP-1-mediated DNA looping.
Reduction in the level of DNA looping abolishes TNF-伪-induced MMP-9 up-regulation.