Stereoselective protecting group free synthesis of d
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- 作者：Daniele Castagnolo ; Lorenzo Botta ; Maurizio Botta
- 关键词：Gulose ; Stereoselective synthesis ; Microwave ; Hexose
- 刊名：Carbohydrate Research
- 出版年：2009
- 出版时间：27 July 2009
- 年：2009
- 卷：344
- 期：11
- 页码：1285-1288
- 全文大小：243 K
文摘
An efficient and stereoselective synthesis of d,l-gulose was described. The key step of the synthetic route is represented by a multicomponent enyne cross metathesis—hetero Diels–Alder reaction which allows the formation of the pyran ring from cheap and commercially available substrates in a single synthetic step. The synthesis of d,l-gulose was accomplished without the use of protecting groups making this approach highly desirable also in terms of atom economy.