Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability
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- 作者：Kienan I. Savage1 ; k.savage@qub.ac.uk" class="auth_mail ; Julia J. Gorski1 ; Eliana M. Barros1 ; Gareth W. Irwin1 ; Lorenzo Manti2 ; Alexander J. Powell1 ; Andrea Pellagatti5 ; Natalia Lukashchuk6 ; Dennis J. McCance1 ; W. Glenn McCluggage1 ; 4 ; Giuseppe Schettino1 ; 7 ; Manuel Salto-Tellez1 ; Jacqueline Boultwood5 ; Derek J. Richard3 ; Simon S. McDade1 ; D. Paul Harkin1 ; d.harkin@qub.ac.uk" class="auth_mail
- 刊名：Molecular Cell
- 出版年：8 May 2014
- 年：2014
- 卷：54
- 期：3
- 页码：445-459
- 全文大小：4322 K
文摘
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BRCA1 forms a complex with mRNA splicing proteins following DNA damage
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The BRCA1-mRNA splicing complex promotes the stability of genes involved in the DDR
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BRCA1-dependent splicing of DDR genes maintains their protein expression
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The BRCA1-mRNA splicing complex is required for DNA repair and genomic stability