- 作者：Leila Ben Othmen ; Anwar Mechri ; Chiraz Fendri ; Muriel Bost ; Guy Chazot ; Lotfi Gaha ; Abdelhamid Kerkeni
- 关键词：Antioxidant enzymes ; Lipid peroxidation ; Oxidative stress ; Schizophrenia ; Unaffected siblings
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2008
- 出版时间：1 January 2008
- 年：2008
- 卷：32
- 期：1
- 页码：155-159
- 全文大小：159 K
Methods
A case-control study carried out on three groups: 60 schizophrenic patients treated with neuroleptics, 33 of their unaffected siblings and 30 healthy controls with no family psychiatric history. Biological markers were measured on fasting patients after a period of tobacco abstinence: RBC antioxidant enzyme activities – superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) – by spectrophotometry and plasma levels of TBARS by spectrofluorimetry.
Results
RBC SOD and CAT activities were significantly lower in schizophrenic patients and their unaffected siblings compared to the control group (P < 0.001). Schizophrenic patients also had significantly lower RBC GSH-Px activity than controls (P = 0.03), whereas their unaffected siblings had significantly higher RBC GSH-Px activity than controls (P = 0.04). Plasma TBARS were higher in schizophrenic patients than their unaffected siblings: 2.1 ± 0.8 μmol/l vs. 1.7 ± 0.6 μmol/l (P = 0.06).
Conclusions
Our results showed a decrease in antioxidant enzyme activities and an increase in lipid peroxidation confirming the existence of oxidative stress in schizophrenic patients treated with neuroleptics. Additionally, this suggests that the increase in GSH-Px activity in unaffected siblings would be a protective mechanism against oxidative stress and damage. Other studies are necessary to confirm these findings.