Memory γδ T Cells-Newly Appreciated Protagonists in Infection and Immunity

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• 作者：Stephen J. Lalor¹ ; Rachel M. McLoughlin¹ ; ^{rachel.mcloughlin@tcd.ie" class="auth_mail" title="E-mail the corresponding author}
• 关键词：γδ T cells ; memory ; infection ; autoimmunity
• 刊名：Trends in Immunology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：37
• 期：10
• 页码：690-702
• 全文大小：2208 K

文摘

Despite the potential for diversity in their T cell receptor, γδ T cells are primarily considered to be innate immune cells. Recently, memory-like γδ T cell responses have been identified in murine models of infection and autoimmunity. Similar memory responses have also been described in human and non-human primate γδ T cells. It has thus become clear that subpopulations of γδ T cells can develop long-lasting memory akin to conventional αβ T cells, with protective and pathogenic consequences. Hence, a re-evaluation of their true capabilities and role in infection and immunity is required. This review discusses recent reports of memory-type responses attributed to γδ T cells and assesses this underappreciated facet of these enigmatic cells.