Signalling pathways mediating type I interferon gene expression

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• 作者：Michael R. Edwards ; Louise Slater ; Sebastian L. Johnston
• 关键词：Virus ; Interferon ; Toll-like receptor ; Signalling
• 刊名：Microbes and Infection
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：9
• 期：11
• 页码：1245-1251
• 全文大小：333 K

文摘

Type I interferon-α/β play an essential role in immunity to viruses. While interferon-β has been used as a model of a complex promoter, many of the signalling pathways leading to interferon-β gene expression remain controversial. Recent milestones include the discovery of Toll-like receptors and RNA helicases that signal via a novel kinase complex composed of IκB kinase-ι/ or TANK binding kinase-1. This review provides a timely summary of this rapidly expanding field, focusing specifically on the various viral RNA binding molecules and their associated signalling pathways.