High immunogenicity of delayed third dose of hepatitis B vaccine in travellers

详细信息    查看全文

• 作者：Yves Jackson ; Franç ; ois Chappuis ; Nathalie Mezger ; Kathi Kanappa ; Louis Loutan
• 刊名：Vaccine
• 出版年：2007
• 出版时间：30 April 2007
• 年：2007
• 卷：25
• 期：17
• 页码：3482-3484
• 全文大小：138 K

文摘

Travellers often present late for the third dose of hepatitis B vaccination and measuring anti-HBs serology is common practice to ensure that these individuals are protected. We assessed the adequacy of immune response in 86 healthy travellers who had their third dose of hepatitis B (HB) vaccine performed more than 1 year (median: 3.4 years; range: 1.1–10.5 years) after the second dose. Eighty-two travellers (95.3 % ) had evidence of sero-protection (anti-HBs titre >10 UI/L) including 16/17 (94.1 % ) travellers who had an interval of more than 5 years between second and third vaccine dose. We did not find any risk factor associated with insufficient response.