Juvenile toxicity testing protocols for chemicals

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• 作者：Aldert H. Piersma ; Elisa C.M. Tonk ; Susan L. Makris ; Kevin M. Crofton ; Rodney R. Dietert ; Henk van Loveren
• 关键词：Juvenile toxicity ; Developmental neurotoxicity ; Developmental immunotoxicity ; OECD TG 443 ; Extended one-generation reproduction toxicity study ; EOGRTS
• 刊名：Reproductive Toxicology
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：34
• 期：3
• 页码：482-486
• 全文大小：186 K

文摘

There is increased awareness of the specific position of children when it comes to hazards of xenobiotic exposures. Children are not small adults, since their exposure patterns, compound kinetics and metabolism, and sensitivity of their developing organs may differ extensively from adults. Current international hazard assessment test guidelines do not specifically address juvenile exposures and effects. In conjunction with the Annual Meeting of the European Teratology Society, a satellite meeting was organized to specifically address juvenile toxicity testing issues for chemicals. The workshop focused on developmental neurotoxicity and developmental immune toxicity testing in juvenile animals. A clear case was made for the importance of juvenile toxicity testing, showing that in animal studies developmental neurotoxicity and immunotoxicity parameters express specifically high sensitivities after exposure during the juvenile period. Additional data will be generated in the coming years, and OECD initiatives will need to further the issue at the global regulatory level.