Synthesis of ABO histo-blood group type I and II antigens

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• 作者：Peter J. Meloncelli ; Todd L. Lowary
• 关键词：ABO histo-blood group ; ABO type I ; ABO type II ; Chemical synthesis ; Trichloroacetimidate ; 7-Octen-1-yl
• 刊名：Carbohydrate Research
• 出版年：2010
• 出版时间：2 November 2010
• 年：2010
• 卷：345
• 期：16
• 页码：2305-2322
• 全文大小：709 K

文摘

The ABO histo-blood group system is one of the most clinically important antigen families. As part of our overall goal to prepare the entire set of the A, B and H type I–VI antigens for a range of biochemical investigations, we report herein the synthesis of the type I and II antigens with a 7-octen-1-yl aglycone. This linker was chosen to facilitate not only the future conjugation of the antigens to a protein or solid support but also the synthesis of the H type I and II octyl glycosides for enzyme kinetic studies.