Apoptosis, mast cell degranulation and collagen breakdown in the pathogenesis of loxoscelism in subcutaneously implanted sponges
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- 作者：Nú ; bia Braga Pereiraa ; e ; nubiologicas@yahoo.com.br" class="auth_mail ; Paula Peixoto Camposa ; e ; Patrí ; cia Martins Parreirasf ; g ; Hé ; lio Chiarini-Garciad ; e ; Teresa Oviedo Socarrá ; sa ; e ; h ; i ; Evanguedes Kalapothakisc ; e ; Silvia Passos Andradeb ; e ; Luciana Moroa ; e
- 关键词：Loxosceles ; Loxoscelism ; Sponge implants ; Apoptosis
- 刊名：Toxicon
- 出版年：15 June 2014
- 年：2014
- 卷：84
- 期：Complete
- 页码：7-18
- 全文大小：5666 K
文摘
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We characterized the effects of Loxosceles similis venom in a sponge implant at 24 h after injecting.
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We measured the mast cells degranulation activity in the implant at 1, 4, and 24 h after injecting.
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We quantified collagen subtypes I and III implant at 1, 4, and 24 h after injecting the venom.
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We showed that apoptosis participates in the pathogenesis of loxoscelism.