A Relay Race on the Evolutionary Adaptation Spectrum

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• 作者：Avihu H. Yona¹ ; ² ; Idan Frumkin³ ; Yitzhak Pilpel³ ; ^{pilpel@weizmann.ac.il" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2015
• 出版时间：22 October 2015
• 年：2015
• 卷：163
• 期：3
• 页码：549-559
• 全文大小：885 K

文摘

Adaptation is the process in which organisms improve their fitness by changing their phenotype using genetic or non-genetic mechanisms. The adaptation toolbox consists of varied molecular and genetic means that we posit span an almost continuous “adaptation spectrum.” Different adaptations are characterized by the time needed for organisms to attain them and by their duration. We suggest that organisms often adapt by progressing the adaptation spectrum, starting with rapidly attained physiological and epigenetic adaptations and culminating with slower long-lasting genetic ones. A tantalizing possibility is that earlier adaptations facilitate realization of later ones.