Effect of phytochemical intervention on dibenzo[a,l]pyrene-induced DNA adduct formation
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- 作者：Gilandra K. Russella ; Ramesh C. Guptaa ; b ; Manicka V. Vadhanamb ; mvvadh01@louisville.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytochrome P450 ; Dibenzo[a ; l]pyrene ; DNA adducts ; Polycyclic aromatic hydrocarbons ; 32P-postlabeling
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：774
- 期：Complete
- 页码：25-32
- 全文大小：1455 K
文摘
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Measure potential of test agents to inhibit phase I metabolizing enzymes.
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Utilization of DNA adduct measurement provides clues to multiple mechanisms.
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Ellagic acid and olitpraz have shown potential to study further for in vivo efficacy.
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Ellagic acid demonstrated significant reduction in CYP1A2 and CYP1B1 activity and also scavenged electrophilic metabolite.
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Oltipraz did not scavenge electrophilic metabolite, but inhibited CYP1A1 and CYP1B1.