Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells
CYP1A1 is the major enzyme of CYP1 family involved in the biotransformation of DMU-212. The cytotoxic effects of DMU-212 are related to the expression of CYP1A1 enzyme. The biological activity of DMU-212 is associated with its metabolic activation to DMU-214.