Nrf2 transcriptional derepression from Keap1 by dietary polyphenols
详细信息 查看全文
- 作者：Henry K. Bayelea ; h.bayele@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Edward S. Debnamb ; Kaila S. Sraia
- 关键词：Antioxidant ; Antioxidant response element ; Detoxification ; Dietary polyphenols ; Cytoprotection
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：469
- 期：3
- 页码：521-528
- 全文大小：1316 K
文摘
- •
Evaluated the transcriptional potencies of dietary polyphenols in chemoprotection.
- •
Polyphenols differentially induce Nrf2 target genes in vitro and in vivo.
- •
Polyphenols depress Nrf2 and its target genes from Keap1 repression.
- •
Their ability to reactivate Keap1-silenced genes may underlie their chemoprotection potential.