Sustainability of 8 % weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome

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• 作者：Charles J. Glueck ; Dawit Aregawi ; Mahlia Agloria ; Magdalena Winiarska ; Luann Sieve ; Ping Wang
• 关键词：peanut ; Δ ; ¹² fatty acid desaturase ; prokaryotical expression ; function identification
• 刊名：Metabolism
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：55
• 期：12
• 页码：1582-1589
• 全文大小：177 K

文摘

In 74 women with polycystic ovary syndrome, treated for 4 years with metformin (MET) and diet, we prospectively assessed whether, and to what degree, weight loss, reduction of insulin resistance, and amelioration of coronary heart disease risk factors could be sustained. We hypothesized that response to MET-diet would not differ by pretreatment body mass index (BMI) classes <25 (normal), ≥25 to <30 (overweight), ≥30 to <40 (obese), and ≥40 (extremely obese).