Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid
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- 作者：Nadia Kazlauskas ; Marcos Campolongo1 ; Luciana Lucchina1 ; Cecilia Zappala ; Amaicha Mara Depino ; adepino@conicet.gov.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Autism spectrum disorder ; HDAC ; Microglia ; Astrocyte ; Hypothalamus-pituitary-adrenal response ; Purkinje cells
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：11-21
- 全文大小：3455 K
文摘
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Early behavioral and inflammatory alterations are evaluated in female pups prenatally exposed to valproic acid.
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Postnatal behavioral alterations are not explained by differences in maternal behavior.
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VPA mice show altered glial density in the postnatal cerebellum and hippocampus.
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An epigenetic mechanism for long-term changes in glial function is proposed.