<p id="p0010">Hypertension is an inflammatory disease that has systemic effects, including calcium loss from the body, and is associated with periodontal disease accompanied by abnormalities in mineralization.p>
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<p id="p0015">Endodontic treatment using reparative cement such as mineral trioxide aggregate (MTA) can restore apical and periapical tissues because of its ability to induce mineralization in tissue at the site of application.p>
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<p id="p0020">The inflammatory response to all materials was greater in hypertensive rates compared with normotensive rats.p>
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<p id="p0025">Mineralization was observed for both gray and white MTA, but this was more pronounced in normotensive rats compared with hypertensive rats.p>
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<p id="p0030">The results indicate that although hypertension can jeopardize tissue repair including mineralization and negatively impact endodontic treatment outcome, MTA still has satisfactory mineralization ability and is therefore the best choice among existing endodontic cements.p>