A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist

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• 作者：Heraldo Mendes Garmes ; M.D. ; Ph.D.p>ap>p> ; p>p>heraldmg@uol.com.brp> ; Oswaldo Rocha Grassiotto ; M.D. ; Ph.D.p>bp> ; Yvens Barbosa Fernandes ; M.D. ; Ph.D.p>cp> ; Luciano de Souza Queiroz ; M.D. ; Ph.D.p>dp> ; José ; Vassalo ; M.D. ; Ph.D.p>dp> ; Daniel Minutti de Oliveira ; M.D.p>ap> ; Cristina Laguna Benetti-Pinto ; M.D. ; Ph.D.p>bp>
• 关键词：FSH-secreting pituitary tumor ; GnRH antagonist ; pituitary adenoma ; ovarian hyperstimulation syndrome
• 刊名：Fertility and Sterility
• 出版年：2012
• 出版时间：January, 2012
• 年：2012
• 卷：97
• 期：1
• 页码：231-234
• 全文大小：259 K

文摘

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Objective

To describe the management of a patient with a pituitary adenoma secreting follicle-stimulating hormone (FSH) associated with ovarian hyperstimulation who was treated with a gonadotropin-releasing hormone (GnRH) antagonist.

Design

<p>Case report.

Setting

<p>University teaching hospital.

Patient(s)

<p>A woman of reproductive age with secondary amenorrhea and ovarian hyperstimulation due to a pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery.

Intervention(s)

<p>Clinical treatment with a GnRH antagonist.

Main Outcome Measure(s)

<p>A decrease in serum estradiol levels.

Result(s)

<p>During the treatment period, ovarian hyperstimulation decreased as shown by a reduction in estradiol levels and an improvement in the patient¡¯s clinical condition and in the ultrasonography parameters.

Conclusion(s)

<p>The GnRH antagonist was found to be effective for the short-term treatment of ovarian hyperstimulation secondary to a pituitary adenoma secreting FSH, thus representing a therapeutic option that should be taken into consideration in such cases.