The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines

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• 作者：Lucie &#x10c ; echová ; ^a ; Petr Jansa^a ; Michal Š ; á ; la^a ; Martin Dra&#x10d ; í ; nský ; ^a ; Antoní ; n Holý ; ^a ; Zlatko Janeba ; ^a ; ^{janeba@uochb.cas.cz}
• 关键词：Microwave-assisted synthesis ; DMF ; Formamides ; Dehalogenative amination ; Purines
• 刊名：Tetrahedron
• 出版年：2011
• 出版时间：4 February 2011
• 年：2011
• 卷：67
• 期：5
• 页码：866-871
• 全文大小：1215 K

文摘

The microwave-assisted decomposition of DMF was thoroughly studied and the reaction conditions (temperature, solvent effect, and effect of additives, such as acids, bases, and salts) were optimized for its use in amination reactions. The applicability of this expedient methodology in purine chemistry and with various formamides is demonstrated.