The idiotype connection: linking infection and multiple sclerosis

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• 作者：Trygve Holmø ; y ; Frode Vartdal ; Anne Lise Hestvik ; Ludvig Munthe ; Bjarne Bogen
• 刊名：Trends in Immunology
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：31
• 期：2
• 页码：56-62
• 全文大小：818 K

文摘

B cells present idiotopes (Id) from their B cell receptor to Id-specific CD4⁺ T cells. Chronic Id-driven T-B cell collaboration can cause autoimmune disease in mice. We propose that Id-driven T-B cell collaboration mediates the development of multiple sclerosis by perpetuating immune responses initiated against infectious agents. During germinal centre reactions, B cells express a multitude of mutated Ids. While most mutations lead to decreased affinity and deletion of the B cell, some B cells could be rescued by Id-specific T cells. Such Id-connected T-B cell pairs might initiate inflammatory foci in the central nervous system. This model may explain the intrathecal synthesis of low-avidity IgG against viruses, and the synthesis of oligoclonal IgG with unknown specificity in multiple sclerosis.