Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma: a clinicopathologic study of 48 patients

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• 作者：Masaya Iwamuro ; MD^a ; ^{iwamuromasaya@yahoo.co.jp" class="auth_mail} ; Hiroyuki Okada ; MD^b ; Katsuyoshi Takata ; MD^c ; Soichiro Nose ; MD^d ; Katsuya Miyatani ; MD^e ; Tadashi Yoshino ; MD^c ; Kazuhide Yamamoto ; MD^a
• 关键词：Follicular lymphoma ; Gastrointestinal endoscopes ; Duodenal neoplasms ; Gastrointestinal lymphoma ; Biopsy
• 刊名：Annals of Diagnostic Pathology
• 出版年：April, 2014
• 年：2014
• 卷：18
• 期：2
• 页码：99-103
• 全文大小：1213 K

文摘

The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II₁: n = 4; II₂: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8%) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy. The initial pathological diagnosis included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n = 4), necrotic tissue (n = 2), duodenitis (n = 1), or suspected lymphoma of unspecified subtype (n = 2). The reasons for these inappropriate diagnoses were insufficient histopathologic analysis lacking CD10 and BCL2 staining (n = 7) and unsuitable biopsy samples taken from erosions or ulcers that contained scanty lymphoma cells or no lymphoid follicles (n = 2). In conclusion, incomplete histopathologic analysis and unsuitable biopsy samples are pitfalls in the diagnosis of gastrointestinal follicular lymphoma.